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Reticuline has anti-inflammation roles in CVDs by targeting the JAK2/STAT3 and NF-B pathway, though the specific mechanisms are still unknown and further verification in atherosclerotic models is required (221)

Front Pharmacol 13:783679 Alemasi A, Gu L, Zhou Y (2024) Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model

For example, the necroptosis inducer RSL3 can release DAMPs, thereby activating T cells and dendritic cells, potentiating anti-tumor immunity, and demonstrating synergistic effects with immune checkpoint blockade, can significantly improve treatment efficacy

Chembiochem 6 , 18391848 (2005)